Figure 5.

Differential Abundance of Highly Correlated Lipid Classes in Nontargeted Mode

(A) Bar chart showing total PC, lysophosphatidylcholine (LysoPC), LysoPE, LysoPA, and MG amounts in mild (N = 12), moderate (N = 36), and severe (N = 46) grade stenotic valves. Data are the average normalized abundance of all putatively identified species (n) in a particular lipid class ± SEM of 96 valve samples. (B) Boxplot chart showing total LysoPA amount (average normalized abundance of 4 putatively identified LysoPA species) in mild (N = 12) and severe (N = 46) cohorts. ∗Significant post hoc differences at p < 0.05 after Tukey adjustment following analysis of variance or independent Student’s t-test. n = number of species in each lipid class; N = number of samples in each category; other abbreviations as in Figure 4.