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. 2020 Dec 16;5(12):1163–1177. doi: 10.1016/j.jacbts.2020.10.001

Figure 6.

Figure 6

LysoPA Species in Valve Leaflets by Targeted LC/MS/MS Analysis

(A) Amount of LysoPA species (16:0, 18:0, 18:1, 18:2, 20:4 and 22:6) in low-gradient (Low) and high-gradient (High) groups. Grouping was performed based on median MPG of the cohort. (B) Total LysoPA amounts (sum of 16:0, 18:0, 18:1, 18:2, 20:4, and 22:6 LysoPA) per milligram of valve tissue extracted in Low (N = 49) and High (N = 52) groups. (C) Amount of LysoPA species (16:0, 18:0, 18:1, 18:2, 20:4, and 22:6) in large AVA (Large) and small AVA (Small) groups. Grouping was performed based on median AVA of the cohort. (D) Total LysoPA amounts (sum of 16:0, 18:0, 18:1, 18:2, 20:4, and 22:6 LysoPA) per milligram of valve tissue extracted in Large (N = 49) and Small (N = 48) groups. (E) Amount of LysoPA species (16:0, 18:0, 18:1, 18:2, 20:4, and 22:6) in 2 extremes of the 5-grade scoring system for valve calcification (C-score = 1 and C-score = 5). (F) Total LysoPA amounts (sum of 16:0, 18:0, 18:1, 18:2, 20:4, and 22:6 LysoPA) per milligram of valve tissue extracted in different grades of valve calcification. Statistical significance at ∗p < 0.05 and ∗∗p < 0.01 after Tukey adjustment following analysis of variance or independent Student’s t-test. CS = calcification score; LC-ESI-MS/MS = liquid chromatography electrospray ionization tandem mass spectrometry; other abbreviations as in Figures 1 and 4.