Figure 7.

LysoPA Relationship to Aortic Stenosis Progression and Its Diagnostic Potential

(A) Amount of lysophosphatidic acid (LysoPA) species (16:0, 18:0, 18:1, 18:2, 20:4, and 22:6) in slow and rapid progressors. Grouping was performed based on the median Vmax (rate of progression per year). (B) Total LysoPA amounts (sum of 16:0, 18:0, 18:1, 18:2, 20:4, and 22:6 LysoPA) per milligram of valve tissue extracted in slow (N = 25) and rapid (N = 25) progressors. (C, D) Pearson correlation (r_p) between tissue levels and plasma levels of 20:4 LysoPA (C) and 18:2 LysoPA (D). ∗ and ∗∗ indicate statistical significance at p < 0.05 and p < 0.01 respectively after Student's t-test.