FIGURE 2.

Comparison of 0.4 × 0.4 × 2.6 mm³ T₂‐ and 1 × 1 × 1 mm³ T₁‐weighted MRI in the same subjects demonstrating better visualization of the inner structure of the hippocampus on 0.4 × 0.4 × 2.6 mm³ T₂‐weighted MRI; a and d‐f are cognitively normal (CN) older adults and b‐c are patients with Mild Cognitive Impairment (MCI). The green arrows point out the hypointense band stratum radiatum lacunosum moleculare (SRLM) which can be observed on the high‐resolution T₂‐weighted MRI scans but not on the 1 mm³ isotropic T₁‐weighted MRI scans. The visualization of SRLM allows for accurate depiction of the width of cornu ammonis (CA) as indicated by the yellow lines in T₂‐weighted MRI but not on T₁‐weighted MRI. Similarly, the high resolution and the depiction of SRLM and alveus (outer hypointense band, red arrows) in the T₂‐weighted MRI, but not T₁‐weighted MRI, allow for clear visualization of the digitations (white asterisks) in the hippocampal head, which is crucial for accurate segmentation. Note that the alveus is visible as a hyperintense band on T₁‐weighted MRI but is less sharp than on the T₂‐weighted MRI