TABLE 3.

Diagnosis and childhood trauma effects on functional connectivity within reward system based on the striatum seeds

Seeds	Brain regions	Voxel	Peak coordinates (x/y/z; MNI)			Peak T values	p‐value (FWEcorr‐cluster)
With moderate‐to‐severe CT < with no or low CT
Left NAcc	Right orbital middle frontal gyrus (BA 10, 47)	22	36	60	−3	4.46	.023
Left ventral caudate	Left orbital inferior and middle frontal gyrus (BA 11)	21	−30	42	−18	3.91	.023
MDD < HC
Right dorsal caudate	Right anterior cingulate cortex (BA32)	20	9	33	24	4.28	.026

Note: 1 subject did not perform the fMRI scan, and the data of 2 participants in the MDD group (1 MDD_moderate‐to‐severe CT, 1 MDD_no or low CT) were excluded from the imaging analyses. Thus, the results of image analyses and subsequent correlation and mediation analyses were based on the sample of 42 MDD_moderate‐to‐severe CT and 21 MDD_no or low CT.

Abbreviations: MDD, patients with major depressive disorder; HC, healthy controls; CT, childhood trauma; BA, Broadmann area; x, y, z, coordinates of peak locations in the Montreal Neurological Institute space (MNI). p < .05, cluster‐level FWE corrected with voxel‐level starting from p < .001 uncorrected.