Figure 2.

Diagram representing the predicted 7-transmembrane domain structure of the Duffy glycoprotein. Indicated are the amino and carboxy terminals and location of the Fya/Fyb polymorphism at amino acid 42. Also indicated, on the third extracellular loop, is the predicted location of the sequences necessary for the binding of monoclonal anti-Fy3. The actual sequence required for binding of human polyclonal anti-Fy3 is not known. Also shown is the predicted region for binding of monoclonal anti-Fy6. N-glycosylation sites are indicated by.