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Desialylation of O-glycans induces unfolding of the mechanosensory domain (MSD) in recombinant GPIb-IX. (A) Overlaid consecutive force-distance traces of pulling MSD under a speed of 200 nm/s without (left) and with (right) prior treatment of α2,3-neuraminidase. (B) Averaged MSD unfolding force without (n=49) or with (n=15) treatment of α2,3-neuraminidase. Error bars are standard error of the mean. *P<0.05 by unpaired t-test.
