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. 2020 Jan 16;106(1):74–86. doi: 10.3324/haematol.2019.238261

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Copyright© 2021 Ferrata Storti Foundation

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Figure 7. — Transplants in secondary NOD scid gamma common chain (NSG) recipients. (A) Percentage of human hematopoietic (huCD45⁺) cells in the peripheral blood (PB) of secondary NSG recipients over time. Each color represents a different patient, as indicated in figure. Continuous line indicates untransduced (UT) cells, dotted line indicates cells transduced with PGK.TCIRG1 vector and dashed line indicates cells transduced with PGK.TCIRG1/dNGFR vector. (B) Percentage of human hematopoietic (huCD45⁺) cells on total CD45⁺ cells in spleen, bone marrow (BM) and thymus at sacrifice. (C) Percentage of CD19⁺ (B lymphocytes, in blue), CD3⁺ (T lymphocytes, in green), CD13⁺ (myeloid cells, in pink), and CD34⁺ (hematopoietic stem and progenitor cells, in yellow) subsets on the total human CD45⁺ cells. (D) Vector copy number (VCN) of in vitro transplanted cells and in tissues (spleen, BM and thymus). Data show mean (D) or mean±standard deviation (B and C).