Figure 1.

Number and types of somatic variants identified by gene and patient both in biopsy and circulating tumor DNA. (A) Heatmap representing somatic variants detected in circulating tumor DNA (ctDNA) in the mutated patients (the "Burden" track represents the mutational load [“burden”] of a patient based on the maximum/minimum number of mutations found in the complete cohort). (B) Unsupervised hierarchical clustering performed among the nine genes to represent the association of alterations (numbers within the clustering represent the number of observed associations between two genes).