Figure 5.

Targeting of chronic myeloid leukemia (CML) niche impacts the quiescence of persisting cells. (A-C) TF1-BAP cells were seeded on top of a HS27A layer and then treated for 3 days with imatinib (IM) (2 M) (A), with or without AG490 (25 M) + E6201 (100 nM) (B and C), and addition of anti-BMP4 (C). Then TF1-BAP (GFP tagged) cells adherent and non-adherent fractions were harvested and analyzed separately for their content of Ki67-PE. Unpaired t-test: *P≤0.05, **P≤0.01, ***P≤0.001. NT: not treated.