Table 2.
Composition of the 5 Å binding pockets.
| Ligand | S1 | α7 (chain A) | α7 (chain B) |
|---|---|---|---|
| Acetylcholine (ach) | Y91, S144, W145, T146, R182, Y184, C187, Y191 | W53, Q55, S77, L106, Q114, L116 | |
| Carbamylcholine (cce) | D428 | Y91, S144, W145, T146, Y184, E185, C186, C187, Y191 | W53, Q55, P102, L104, A105, L106, Q114, Y115, L116, P117 |
| Cytisine (c5e) | A89, Y91, S144, W145, T146, Y184, E185, C186, C187, Y191 | W53, L104, A105, L106, Q114, Y115, L116 | |
| Epibatidine (epj) | A89, Y91, S144, W145, T146, Y184, E185, C186, C187, Y191 | W53, L104, A105, L106, Q114, Y115, L116 | |
| Galantamine (gnt) | G381, V382, L387, L390, D428, T430, L517 | Y91, K141, W145, R182, Y184, E185, D193 | S34, L36, W53, D160, S162, G163, Y164, I165 |
| Nicotine (nct) | D428 | Y91, S144, W145, T146, R182, Y184, E185, C186, C187, Y191 | W53, L54, Q55, L106, Q114, L116 |
| Succinylcholine (sck) | Y91, N92, S144, W145, T146, Y184, E185, C186, C187, Y191 | S34, L35, L36, W53, Q55, L106, Q114, L116, D160, G163, Y164 | |
| Varenicline (qmr) | Y380, G381, P412, D427, D428, F429, T430 | W145, F183, Y184, E185, C186, C187, Y191 | W53, L54, Q55, M56, Q114, Y115, L116 |