Fig. 5.

NAcc activity to non-gains statistically mediates the association between AIns-NAcc structural coherence and SPSRQ-C drive at follow-up.

Statistical mediation analysis of a model in which AIns-NAcc tract coherence correlates with greater future SPSRQ-C drive through decreased NAcc activity during non-gain anticipation. The model includes sex, age, and initial SPSRQ-C drive as covariates of no interest. AIns-NAcc tract coherence was associated with greater future SPSRQ-C drive (c). The indirect pathway statistically mediated this association, such that AIns-NAcc tract coherence was associated with decreased NAcc activity (a), and NAcc activity was associated with decreased future drive (b). Including functional NAcc activity as a mediating variable reduced the direct pathway to no statistical significance (c’).