Fig. 6.

Schematic representation of inhibitory synapses in the absence and presence of artemisinins. This scheme shows that in the absence of artemisinins (Left) gephyrin clusters the receptors required for inhibitory neurotransmitters at postsynaptic sides, while PDXK contributes to the biosynthesis of neurotransmitters at presynaptic terminals by producing the PLP cofactor for GAD and SHMT enzymes. In contrast, in the presence of artemisinins (Right), gephyrin-mediated clustering of receptors at postsynaptic sites is impaired while neurotransmitter biosynthesis at presynaptic terminals is inhibited.