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. 2020 Dec 16;117(52):33639–33648. doi: 10.1073/pnas.2013663117

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Fig. 5. — Recovery of t-LTP with increasing pairing frequency. (A) Effects of the stimulation frequency on synaptic changes induced by a pre-post protocol at +10 ms with a single postsynaptic action potential in 1.8 mM extracellular calcium. For 0.3 Hz, t-LTD is induced. For 3 Hz, no synaptic changes are induced. For 5 or 10 Hz, t-LTP is induced. Increasing the pairing frequency restores t-LTP. To facilitate the comparison between the data, the first time point after pairing at 3, 5, and 10 Hz has been set to that at 0.3 Hz. *P < 0.02. (B) Effects of the stimulation frequency on synaptic changes induced by a pre-post protocol at +10 ms with a single postsynaptic action potential in 1.3 mM extracellular calcium. For 0.3 Hz, no synaptic change is induced. For 10 Hz, t-LTP is induced. Increasing the pairing frequency restores t-LTP. To facilitate the comparison between the data, the first time point after pairing at 10 Hz has been set to that at 0.3 Hz. *P < 0.01.