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. 2020 Dec 16;117(52):33639–33648. doi: 10.1073/pnas.2013663117

Fig. 6.

Fig. 6.

Recovery of t-LTD in 1.3 mM. (A) Role of postsynaptic spike number on synaptic changes induced by a post-pre protocol at −25 ms at a pairing frequency of 0.3 Hz in 1.3 mM extracellular calcium. For a single action potential, no change is induced (black). For three action potentials, t-LTD is induced (orange). Thus, increasing the number of postsynaptic action potentials allows t-LTD to recover. *P < 0.01. (B) Effects of stimulation frequency on the induction of synaptic plasticity by a post-pre protocol at −25 ms with a single postsynaptic action potential in 1.3 mM extracellular calcium. For 0.3 Hz, no change is induced (black). For 10 Hz, t-LTD is induced (orange). Thus, increasing pairing frequency allows t-LTD to recover. To facilitate the comparison between the data, the first time point after pairing at 10 Hz has been set to that at 0.3 Hz. *P < 0.01.