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Pol ι loss renders unique synthetic lethality with FA deficiency. (A) BF distribution of DNA polymerase subunits from the FA synthetic lethality screens (green dots) and the Avana set (425 screens form Q4 2018) of genome-wide fitness screens (black dots). (B–D) Clonogenicity of Pol ι, η, and κ gRNA knockdown in HCT116 wild-type cells and FANCL−/− cells. (E–G) Cell proliferation of Pol ι, η, and κ gRNA knockdown in HCT116 wild-type cells and FANCL−/− cells.
