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. 2020 Jul 22;177(2):405–419. doi: 10.1093/toxsci/kfaa118

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Figure 6. — Effect of AZD7762 and AZD8542 on 17β-estradiol (E2) secretion and oocyte maturation in vitro. A, E2 secretion levels on day 8 of encapsulated in vitro follicle growth (eIVFG) after follicles were treated with different concentrations of AZD8542 and AZD7762 for 24 h. B, Oocyte metaphase II (MII) percentages from follicles treated with different concentrations of AZD8542 and AZD7762 for 24 h. Error bar: SD; ***p < .001 compared with control group. The red cross marks indicated no follicles were selected for in vitro ovulation because of the 100% follicle death upon AZ-H treatment. N = 8–12 follicles in each experimental group and 3 replicates were performed.