Table 1.

Summary Distribution of Susceptibilities of the 98 Clinical Isolates of Aspergillus spp. to Nine Antifungal Drugs as Determined Based on the M38-3A Protocol Established by the Clinical and Laboratory Standards Institute (CLSI)

Species/Number		MIC or MEC (µg/mL) for
		AFG	CFG	MFG	ITZ	VRZ	RVZ	PSZ	ISZ	AmB
A. fumigatus complex (57)	MIC range	≤0.015–0.03	0.06–1	≤0.015–0.12	0.25–8	0.12–16	0.25–16	0.06–1	0.25–16	1–4
	MIC50	≤0.015	0.25	0.03	0.5	0.5	1	0.25	0.5	1
	MIC 90	0.03	0.25	0.12	1	0.5	2	0.25	1	2
	GM	0.021	0.221	0.034	0.615	0.443	0.765	0.187	0.711	1.245
A. flavus complex (23)	MIC range	≤0.015–0.25	0.12–0.25	≤0.015–0.25	0.12–0.5	0.5–2	1–2	0.12–1	0.5–2	1–4
	MIC50	0.03	0.12	0.06	0.25	1	1	0.25	1	2
	MIC 90	0.06	0.25	0.12	0.5	2	2	1	2	2
	GM	0.034	0.169	0.057	0.291	0.970	1.128	0.328	1.031	1.620
A. niger complex (15)	MIC range	≤0.015–0.03	0.06–0.12	0.03–0.25	0.5–16	0.5–16	0.5–16	0.25–2	0.5–16	0.5–2
	MIC50	≤0.015	0.12	0.12	1	1	2	0.5	2	1
	MIC 90	0.03	0.12	0.25	1	2	4	0.5	4	2
	GM	0.020	0.109	0.090	0.912	1.260	1.910	0.416	2.297	1.05
A. sydowii (1)	MIC range	0.06	0.03	0.03	1	2	2	1	2	2
A. terreus (1)	MIC range	≤0.015	0.12	≤0.015	0.25	2	2	0.12	1	2
A. nidulans (1)	MIC range	0.06	0.06	0.03	0.5	0.25	0.25	0.06	0.25	2

Abbreviations: AFG, anidulafungin; CFG, caspofungin; MFG, micafungin; ITZ, itraconazole; VRZ, voriconazole; RVZ, ravuconazole; PSZ, posaconazole; ISZ, isavuconazole; AmB, amphotericin B; GM, geometric means; MIC, Minimal inhibitory concentration; MEC, Minimal effective concentration; MIC₅₀, MIC/MEC at which 50% of the isolates tested were inhibited; MIC₉₀, MIC/MEC at which 90% of the isolates tested were inhibited.