Table 2.

Minimal Inhibitory Concentrations of Antifungal Drug-Resistant Isolates of Aspergillus spp. in Our Study as Determined Based on the M38-3A Protocol Established by the Clinical and Laboratory Standards Institute (CLSI)

Species	Number	MIC (µg/mL) for						cyp51A
		ITZ	VRZ	RVZ	PSZ	ISZ	AmB
A. fumigatus	CMXY 13,113	8	16	16	1	16	†	TR46/Y121F/T289A
A. fumigatus	CMXY 15,837	4	†	†	†	†	†	F46Y, G89G, M172V, N248T, D255E
A. fumigatus	CMXY 28,940	†	†	†	0.5	2	†	F46Y, G89G, M172V, N248T, D255E
A. fumigatus	CMXY 25,241	†	†	†	1	†	†	#
A. fumigatus	CMXY 10,234	†	†	†	†	†	4	#
A. fumigatus	CMXY 14,287	†	†	†	†	†	4	#
A. effusus	CMXY 22,227	†	†	†	1	†	†	##
A. flavus	CMXY 22,879	†	†	†	1	2	4	##
A. effusus	CMXY 27,481	†	†	†	1	2	4	##
A. flavus	CMXY 30,197	†	†	†	1	†	†	##
A. tubingensis	CMXY 27,207	16	16	16	2	16	†	##

Notes: “†” means the MIC ≤ epidemiological cutoff values; “#” means the mutant site of cyp51A gene was not be found; “##” means the cyp51A gene were not analyzed.

Abbreviations: ITZ, itraconazole; VRZ, voriconazole; RVZ, ravuconazole; PSZ, posaconazole; ISZ, isavuconazole; AmB, amphotericin B; MIC, minimal inhibitory concentration.