Table 2.

Differentiating features of solid organ and hematologic malignancies and related infectious pathogens

	Hematologic malignancies	Solid organ malignancies
Malignancy incidence	Less common (leukemia, lymphoma, multiple myeloma)	More common (carcinoma, sarcoma)
Risk factors for infection	Severe prolonged neutropenia from chemotherapy and immunosuppression Altered permeability in mucosal barrier injury from cytotoxic chemotherapy	Multifactorial: obstruction from tumor, disruption of natural barriers
Distinctive entities	Febrile neutropenia Blood stream infections (bacteremia, candidemia) Neutropenic enterocolitis	Ascending cholangitis Abscesses (hepatic, renal, prostate) Bowel obstruction and necrosis, perforation Fistulas Obstructive uropathy Surgical site infections
Most common pathogens	Enterobacteriaceae Cytomegalovirus Invasive aspergillosisa Candida	Methicillin-resistant S. aureus Pseudomonas aeruginosa Clostridium difficile Extended spectrum beta-lactamase-producing organisms e.g. Klebsiella pneumonia Vancomycin-resistant enterococci Polymicrobial infectionsb,c

^aRuiz Camps [13]

^bSutton [1]

^cRolston [3]