Table 3.
Effect of fermented red bean extract (NRBE) on blood urea nitrogen (BUN), serum creatinine, urine creatinine, 24-h urine creatinine clearance rate (Ccr), and urinary albumin excretion (UAE) in diabetic rats.
| Group | NC | DC | L | M | H |
|---|---|---|---|---|---|
| BUN (mg/dL) | 19.25 ± 0.81 | 43.41 ± 1.41*a | 42.65 ± 2.74a | 39.77 ± 4.65a | 40.81 ± 2.02a |
| Serum creatinine (mg/mL) | 1.79 ± 0.12 | 2.26 ± 0.13 | 2.15 ± 0.14 | 2.42 ± 0.28 | 1.94 ± 0.08 |
| Urine creatinine (mg/24 hr) | 61.07 ± 5.91 | 10.04 ± 0.25*a | 10.89 ± 0.16a | 11.50 ± 0.21ab | 10.77 ± 0.07a |
| 24-h Ccr (mL/min) | 0.75 ± 0.19 | 1.11 ± 0.29*a | 0.96 ± 0.24b | 0.77 ± 0.27c | 1.06 ± 0.16ab |
| UAE (mg/min) | 6.80 ± 1.8 | 53.85 ± 2.05*a | 28.44 ± 2.80b | 23.90 ± 3.28b | 30.47 ±1.12b |
1Values are mean ± SEM, 8 rats per group.
2NC: normal control, DC: diabetic control, L: diabetes with low dose of NRBE (100 mg/kg BW), M: diabetes with medium dose of NRBE (200 mg/kg BW), H: diabetes with high dose of NRBE (500 mg/kg BW).
*
Significantly different with NC at p < 0.05.
a~b
Means not sharing a common superscript in the same row are significantly different at p < 0.05.