TABLE 3.
Mortality According to Transgression Occurrence
| Simple Models Include Only One Transgression, Adjusted for Treatment, Severity, Gender, and Age |
Full Model Includes All Transgressions Except CPP, ICP, Pbto2, and Temperature; n = 752 |
Final Model After Backward Selection, Using α = 0.05 As Criteria for Removal |
|||||
|---|---|---|---|---|---|---|---|
| Transgression Variable | n Used | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) |
| Pao2 | 811 | 0.1924 | 0.741 (0.472–1.163) | 0.0923 | 0.623 (0.359–1.081) | 0.0253 | 0.546 (0.321–0.928) |
| Glucose (high) | 856 | 0.0033a | 2.070 (1.274–3.363) | 0.0226 | 1.940 (1.098–3.428) | 0.0168 | 1.970 (1.130–3.433) |
| Glucose (low) | 856 | 0.0478 | 0.557 (0.312–0.994) | 0.0254 | 0.472 (0.244–0.912) | 0.0222 | 0.472 (0.248–0.898) |
| CPP | 457 | 0.0059 | 2.936 (1.364–6.321) | ||||
| International nor- malized ratio | 798 | < 0.0001a | 5.233 (3.176–8.622) | < 0.0001a | 4.585 (2.533–8.300) | < 0.0001a | 5.063 (2.929–8.750) |
| Platelets | 856 | < 0.0001a | 4.389 (2.211–8.714) | 0.1217 | 1.914 (0.841–4.353) | ||
| O2 | 862 | 0.3802 | 0.818 (0.522–1.282) | 0.3642 | 0.777 (0.451–1.340) | ||
| Hemoglobin | 855 | 0.2810 | 1.280 (0.817–2.007) | 0.6863 | 0.889 (0.501–1.576) | ||
| ICP | 460 | 0.0702 | 1.839 (0.951–3.556) | ||||
| Mean arterial pressure (65) | 853 | 0.4130 | 0.817 (0.503–1.327) | 0.1353 | 0.608 (0.316–1.168) | ||
| Pbto2 | 152 | Quasi-complete separation | |||||
| SBP (high) | 863 | 0.0012a | 0.466 (0.293–0.741) | 0.0172 | 0.526 (0.310–0.892) | 0.0127 | 0.518 (0.309–0.869) |
| SBP (low, 90) | 863 | 0.2688 | 1.280 (0.826–1.984) | 0.4008 | 1.293 (0.710–2.355) | ||
| Temperature (high) | 862 | 0.0308 | 0.598 (0.375–0.954) | ||||
| Temperature (low) | 862 | < 0.0001a | 2.841 (1.819–4.435) | ||||
CPP = cerebral perfusion pressure, ICP = intracranial pressure, OR = odds ratio, Pbto2 = brain tissue oxygen tension, SBP = systolic blood pressure.
a
Significant after Holm correction for multiple comparisons.