TABLE 4.
Functional Outcome According to Transgression Occurrence in the Full Cohort
| Simple Models Include Only One Transgression, Adjusted for Treatment, Severity, Gender, and Age | Full Model Includes All Transgressions Except CPP, ICP, Pbto2, and Temperature; n = 726 | Final Model After Backward Selection, Using a = 0.05 As Criteria for Removal | |||||
|---|---|---|---|---|---|---|---|
| Transgression Variable | n Used | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) |
| Pao2 | 782 | 0.0008a | 1.724 (1.254–2.372) | 0.1344 | 1.326 (0.916–1.920) | ||
| Glucose (high) | 823 | < 0.0001a | 2.046 (1.505–2.782) | 0.0080 | 1.613 (1.133–2.296) | 0.0010a | 1.740 (1.250–2.423) |
| Glucose (low) | 823 | 0.8954 | 0.977 (0.692–1.380) | 0.2795 | 0.810 (0.553–1.187) | ||
| CPP | 444 | 0.0515 | 1.612 (0.997–2.606) | ||||
| International normalized ratio | 769 | 0.0002a | 2.051 (1.404–2.994) | 0.0231 | 1.638 (1.070–2.507) | 0.0046a | 1.761 (1.190–2.605) |
| Platelets | 823 | 0.8621 | 1.056 (0.570–1.955) | 0.0791 | 0.538 (0.270–1.075) | ||
| O2 | 829 | 0.2957 | 1.175 (0.868–1.591) | 0.2150 | 0.802 (0.566–1.137) | ||
| Hemoglobin | 822 | 0.0001a | 1.856 (1.358–2.537) | 0.0276 | 1.518 (1.047–2.201) | ||
| ICP | 448 | 0.0005a | 2.486 (1.493–4.140) | ||||
| Mean arterial pressure (65) | 821 | 0.7350 | 1.058 (0.763–1.468) | 0.1127 | 0.716 (0.474–1.082) | ||
| Pbto2 | 143 | 0.3467 | 1.442 (0.673–3.088) | ||||
| SBP (high) | 830 | 0.0190 | 1.446 (1.062–1.967) | 0.5009 | 1.127 (0.795–1.598) | ||
| SBP (low, 90) | 830 | 0.0235 | 1.411 (1.047–1.900) | 0.2455 | 1.249 (0.858–1.816) | ||
| Temperature (high) | 829 | 0.0009a | 1.788 (1.270–2.516) | ||||
| Temperature (low) | 829 | 0.0033a | 1.583 (1.165–2.150) | ||||
CPP = cerebral perfusion pressure, ICP = intracranial pressure, OR = odds ratio, Pbto2 = brain tissue oxygen tension, SBP = systolic blood pressure.
a
Significant after Holm correction for multiple comparisons.