Figure 8. Sox9 deletion in the AF significantly impacts transcriptional programming related to the immune response, cytoskeleton, cell cycle, extracellular matrix, and ion transport.

(A) Thematic organization of concepts determined by literature correspondence to significantly differentially upregulated genes in the AF of Sox9^cKO mice, emphasizing immune responses (blue), the cytoskeleton (red), the cell cycle (orange), and the extracellular matrix (yellow) as prominent physiological features impacted by SOX9 loss of function. (B) Downregulated DEGs in the AF of Sox9^cKO mice indicating the extracellular matrix (yellow) and ion transport (pink) as the most prominent physiological features impacted by Sox9 deletion. (n=17 discs/animal, 4 animals/genotype)