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. 2021 Jan 1;12(3):740–753. doi: 10.7150/jca.48245

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Genetic mutations in CCRGs and their associations with copy number alteration frequency and OS of BC patients (cBioPortal). (A) A high mutation rate (43%, 641/1904) of CCRGs was observed in BC patients. CCNE2 was ranked as the gene with the highest number of genetic alterations, with a 22% mutation rate. (B) Putative DNA copy number alterations showed more genes with copy number alterations clustered in the altered group, and (C) the top 10 genes with the highest alteration frequencies were markedly enriched in the altered group. (D) Genetic alterations in CCRGs were associated with shorter OS in BC patients.