Fig. 1.

48-year old man with confirmed COVID-19 pneumonia. At hospital admission, HRCT images on axial (a) and coronal (b) planes showed bilateral, mostly peripheral GGO and consolidations. The two horizontal white lines in (b) delimit the upper, middle, and lower lung zones, which were identified to apply the semi-quantitative score (see the text for details). The scheme in (c) resumes how each of the three readers (R1, R2, and R3) assigned the TFS for GGO, consolidation, and crazy-paving pattern, thus allowing the calculation of TLS as the sum of all the TFSs. For all the readers, TLS was >6, a feature we found to be predictive for short-term occurrence of severe disease. After one day, the patient developed respiratory failure [Italian Society of Emergency Medicine (SIMEU) phenotype III disease]