Figure 2.

Molecular modeling of CSF-1R binding to its ligands. Molecular modeling was generated as described in A) representation of the three-dimensional crystal structure of the CSF-1/CSF-1R complex. In red and orange: monomers of CSF-1; and in blue and purple: monomers of CSF-1R. B) Representation of the three-dimensional crystal structure of the IL-34/CSF-1R complex. In green and light green: monomers of IL-34; and in blue and purple: monomers of CSF-1R.