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The novel hydroxyprotoilludene was identified as 8α-hydroxy-6-protoilludene by NMR spectroscopy. This is the first step in the biosynthesis of melleolides with the carbon double bond in the 6,7 position (like armillyl orsellinate). The cytochrome P450 monooxygenase that converts this intermediate into 6-hydroxy-7-protoilludene; the first step towards the major metabolites in A. gallica (e.g., melleolide I) is still unknown
