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. 2021 Jan 3;48(2):261–272. doi: 10.1007/s10928-020-09730-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Visual predictive check plots for DEX following administration of 6 mg DEX-P IM (upper panel) and DEX-P PO (lower panel) doses. Symbols represent observed plasma concentrations, continuous line is the median, and dashed lines are 5th and 95th percentiles of observed values. The shaded regions are model-predicted confidence intervals for these percentiles. The insets show the plots over the first 6 h for better visualization. The horizonal line indicates the limit of quantitation (0.1 ng/mL)