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. 2021 Jan 3;48(2):261–272. doi: 10.1007/s10928-020-09730-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Simulated corticosteroid plasma concentrations for indicated dosing regimens. The solid line is the median of N = 200 subjects. The shaded regions represent 5th and 95th percentiles. The vertical line denotes the limit of quantification. Parameters used for simulations are listed in Tables 3 and 4