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Inhibition of TNF-α by compounds 3a-j.
| Molecules | TNF-α inhibition | |
|---|---|---|
| % inhibition @ 10 μM | IC50 (μM) | |
| 3a | 66.5 | 7.12±0.48 |
| 3b | 67.9 | 7.02±0.72 |
| 3c | 76.1 | 5.47±0.69 |
| 3d | 75.6 | 5.92±0.89 |
| 3e | 56.8 | n.d. |
| 3f | 62.4 | 7.58±0.55 |
| 3g | 61.7 | 7.45±0.37 |
| 3h | 53.6 | n.d. |
| 3i | 77.3 | 5.14±0.34 |
| 3j | 75.4 | 5.65±0.29 |
| Rolipram | 97.7 | 0.91 ±0.02 |
| Thalidomide | n.d. | 198.91±6.32 |
n.d. = not determined.
