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. 2020 Nov 12;49(D1):D1289–D1301. doi: 10.1093/nar/gkaa1033

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Features of identified driver genes. (A). A significant positive correlation between average mutation burden in a cancer type and the number of identified driver genes. (B, C). OncoVar identified many known driver genes which are consistent with results by other methods including CGC (49), CTAT (31), OncoKB (50), IntOGen (37) and several novel driver genes. (D). Percent of genes among different loss-of-function genes observed/expected upper bound fraction (LOEUF) (28) in a normal population from gnomAD.