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. 2020 Oct 21;49(D1):D855–D861. doi: 10.1093/nar/gkaa885

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Web interface of the database, showing a list of all included gRNA sequences and which, if any, GENCODE gene name they target. Their respective target distributions across the genome are visualised as a barcode-type histogram, allowing a first assessment of their reported specificity. Upon clicking on or searching for a specific guide (inset), the website shows its full reported off-target profile, i.e. gene names of target loci, cleavage rates and epigenetic markers at the target site, hyperlinked to the respective source. Clicking on a gene name opens the vicinity of the respective cut site in a genome browser.