Figure 2.

Overview of HERB-REF. (A) Statistics on the number of herb/ingredient-related references published in each year. The blue line represents the total references from manual curation, and the red line represents the references with curated targets/diseases. (B) The number of curated herbs/ingredients, targets/diseases, and their associations from HERB-REF are shown in bar plots, with the four facets showing four types of associations: herb-target, herb-disease, ingredient–target, and ingredient–disease. (C) HERB-REF datasets were used to search and rank promising herbs or ingredients for cancer-related diseases that could be connected to immuno-oncology related targets. The number of herbs/ingredients obtained by target-based search and/or disease-based search was shown in a Venn plot. (D) The selected herbs/ingredients that were supported by both target-based and disease-based search were illustrated in a dot plot, with the X- and Y-axis showing the number of references from each search, respectively. The density of dots representing the number of dots at the same point are represented in color scales.