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Comparing gene essentiality between human-mouse orthologs. Here only genes with one-to-one human-mouse orthologous relationships are included. Mouse essential genes were obtained from IMPC (blue) and MGI (green) databases. The two human essential gene dataset, RNAi and CRISPR–Cas9 were generated by selecting those that were essential in over 50% the cell lines of a tissue; tissues with less than six cell lines were excluded from this analysis.
