Figure 1.

INTEDE statistics of (i) the DMEs, and their corresponding drug(s) and tissue/disease specific protein abundances (orange) and (ii) three types of DME interactions: MICBIOs (green), HOSPPIs (blue) and XEOTICs (red). MICBIO determines the evolving and dynamic nature of metabolizing capacity and the interpersonal variability of drug metabolism; HOSPPI is essential for predicting in vivo efficacy/clearance based on the in vitro data, and revealing the mechanisms underlying drug resistance and toxicity; XEOTIC is one of the leading factors of the metabolism-based drug-drug interaction and the constant inspiration of clinical treatment optimization.