Table 2.
Number of entries of microbiota - active substances interactions in each category/subcategory of substances. One substance may belong to multiple subcategories
| Substance category—subcategory | No. of substances | No. of interactions (bacteria alter substances) | No. of interactions (substances alter bacteria abundance) | Total no. of interactions |
|---|---|---|---|---|
| Therapeutic substance (all) | 1074 | 4134 | 7081 | 11 215 |
| Therapeutic substance—approved drug (human) | 980 | 3947 | 6544 | 10 491 |
| Therapeutic substance—approved drug (veterinary medicine) | 16 | 0 | 362 | 362 |
| Therapeutic substance—drug class | 41 | 51 | 139 | 190 |
| Therapeutic substance—investigational drug | 30 | 118 | 47 | 165 |
| Dietary substance (all) | 103 | 42 | 267 | 309 |
| Dietary substance—artificial sweeteners | 5 | 6 | 14 | 20 |
| Dietary substance—dietary Compounds | 72 | 46 | 138 | 184 |
| Dietary substance—drinks | 20 | 1 | 80 | 81 |
| Dietary substance—foods | 13 | 0 | 34 | 34 |
| Herbal substance (all) | 119 | 367 | 547 | 914 |
| Herbal substance—medicinal herb | 24 | 2 | 115 | 117 |
| Herbal substance—medicinal herbal compounds | 87 | 364 | 405 | 769 |
| Herbal substance—TCM formula | 5 | 0 | 24 | 24 |
| Environmental substance (all) | 142 | 37 | 716 | 753 |
| Environmental substance—heavy metals | 10 | 4 | 158 | 162 |
| Environmental substance—persistent organic pollutants | 14 | 0 | 94 | 94 |
| Environmental substance—pesticides | 26 | 0 | 269 | 269 |