TABLE 3.
Changes in subcutaneous adipose tissue vitamin D3 and 25(OH)D3 concentrations from baseline to 3 mo in a pilot clinical trial of vitamin D3 supplementation1
| Vitamin D3, pg/mg | 25(OH)D3, pg/mg | |||||
|---|---|---|---|---|---|---|
| Baseline | 3-mo | Mean change from baseline to 3 mo | Baseline | 3-mo | Mean change from baseline to 3 mo | |
| 2000 IU/d (n = 8) | 10.8 ± 4.6 | 21.3 ± 9.3 | 10.6 (5.0, 16.1) | 1.1 ± 0.3 | 2.5 ± 0.8 | 1.4 (0.9, 1.8) |
| 4000 IU/d (n = 7) | 9.1 ± 7.8 | 31.8 ± 14.4 | 22.6 (16.7, 28.6) | 1.1 ± 0.3 | 3.5 ± 0.3 | 2.4 (1.9, 2.8) |
| Absolute difference | 12.1 (4.0, 20.2) | 1.0 (0.3, 1.7) | ||||
| Fold difference | 2.15 (1.34, 4.10) | 1.73 (1.18, 2.79) | ||||
1
Values are means ± SDs or means (95% CIs). Data are from pilot study 2. Linear mixed-effects models were used to estimate change between baseline and 3 mo within group, absolute difference in change between groups, and associated CIs. Estimates and CIs for the fold difference in change between groups were obtained through bootstrap methods with 2000 replicates. SI conversion factors: vitamin D3, 1 pg/mg = 2.6 nmol/kg; 25(OH)D3, 1 pg/mg = 2.5 nmol/kg. 25(OH)D3, 25-hydroxyvitamin D3.