TABLE 3.
Vitamin B-12 | β (95% CI) | P-trend |
---|---|---|
Model 1 | −0.135 (−0.224, −0.047) | 0.003 |
Model 2 | −0.128 (−0.217, −0.038) | 0.005 |
Model 3 | −0.119 (−0.208, −0.029) | 0.009 |
1Vitamin B-12 deficiency was defined as <148 pmol/L or MMA > 271 nmol/L. Model 1: adjusted for age (y), sex (premenopausal or postmenopausal female with estrogen use, female postmenopausal with no estrogen use, or male), BMI (in kg/m2), physical activity score, diabetes (yes/no), education level (≤8th grade, 9th–12th grade, or college), smoking (past, current, or none), alcohol use (heavy, none, or moderate), and apoE ε4 carrier (yes/no). Model 2: Model 1 + plasma vitamin B-6 (pyridoxal-5-phosphate; nmol/L). Model 3: Model 2 + plasma folate (nmol/L).