Table 2.

Change in glycemic control measures

	Baseline (days 1–14)	Final phase (days 76–90)	Change	95% CI For Change	P‐value
Time in range 70–180 mg/dL (h) †	15.0 ± 4.0	16.7 ± 3.7	1.7 ± 3.0	(1.1, 2.3)	<0.0001
Mean glucose (mg/dL)	167 ± 26	156 ± 24	−11 ± 23	(−16, −6)	<0.0001
Mean glucose (mmol/L)	9.3 ± 1.5	8.7 ± 1.3	−0.6 ± 1.3	(−0.9, −0.3)	<0.0001
eA1c (%)	7.46 ± 0.91	7.07 ± 0.84	−0.39 ± 0.81	(−0.56, −0.22)	<0.0001
eA1c (mmol/mol)	58.0 ± 10.0	53.8 ± 9.2	−4.3 ± 8.9	(−6.1, −2.4)	<0.0001
Glucose <70 mg/dL
Time (h) †	0.51 ± 0.93	0.47 ± 0.63	−0.04 ± 0.83	(−0.21, 0.13)	0.6354
Time (h) in day ‡	0.25 ± 0.47	0.27 ± 0.41	0.01 ± 0.43	(−0.07, 0.10)	0.7437
Time (h) in night §	0.25 ± 0.59	0.20 ± 0.31	−0.06 ± 0.54	(−0.17, 0.05)	0.3139
Events †	0.35 ± 0.47	0.37 ± 0.44	0.02 ± 0.44	(−0.07, 0.11)	0.7023
AUC (h × mg/dL) †	6.30 ± 15.69	4.80 ± 8.53	−1.50 ± 13.08	(−4.21, 1.21)	0.2753
Glucose <45 mg/dL
Time (h) †	0.07 ± 0.30	0.04 ± 0.13	−0.03 ± 0.26	(−0.08, 0.03)	0.3118
Events †	0.05 ± 0.16	0.04 ± 0.10	−0.01 ± 0.14	(−0.04, 0.01)	0.3265
AUC (h × mg/dL) †	0.34 ± 1.50	0.19 ± 0.58	−0.15 ± 1.28	(−0.42, 0.12)	0.2628
Glucose <55 mg/dL
Time (h) †	0.16 ± 0.48	0.11 ± 0.26	−0.05 ± 0.39	(−0.13, 0.03)	0.2128
Events †	0.12 ± 0.26	0.09 ± 0.18	−0.04 ± 0.20	(−0.08, 0.01)	0.0884
AUC (h × mg/dL) †	1.43 ± 5.25	0.92 ± 2.43	−0.51 ± 4.46	(−1.43, 0.41)	0.2758
Glucose >180 mg/dL
Time (h) †	8.5 ± 4.0	6.8 ± 3.7	−1.6 ± 3.4	(−2.3, −0.9)	<0.0001
Events †	2.59 ± 0.87	2.36 ± 0.77	−0.23 ± 0.74	(−0.38, −0.08)	0.0037
Glucose >240 mg/dL
Time (h) †	3.2 ± 2.5	2.1 ± 2.3	−1.0 ± 2.1	(−1.5, −0.6)	<0.0001
Events †	1.35 ± 0.80	0.99 ± 0.81	−0.35 ± 0.68	(−0.50, −0.21)	<0.0001
Glucose >300 mg/dL
Time (h) †	0.9 ± 1.2	0.6 ± 1.0	−0.4 ± 1.0	(−0.6, −0.1)	0.0013
Events †	0.48 ± 0.45	0.34 ± 0.47	−0.14 ± 0.40	(−0.23, −0.06)	0.0011

Total n = 92. Data presented as the mean ± standard deviation.

AUC, area under the curve; CI, confidence interval; eA1c, estimated glycated hemoglobin.

^†Per 24 h day.

^‡Per 17 h day

^§Per 7 h night.