Skip to main content
. 2020 Jul 23;12(1):35–47. doi: 10.1111/jdi.13319

Figure 1.

Figure 1

The glucose‐lowering effects of sodium–glucose cotransporter 2 inhibitor (SGLT2i) are attenuated in lean mice under free feeding conditions. (a) Food intake in lean hepatic gluconeogenic enzyme gene reporter (L‐G6pc‐GLuc) mice with normal chow (NC) with or without SGLT2i for 4 weeks under free feeding (FF). (b–g) L‐G6pc‐GLuc mice were administered NC with (+) or without (−) SGLT2i for 4 weeks under controlled feeding (CF) or FF. (b) Body weight. (c) Blood glucose levels. (d) Plasma insulin levels. (e) Plasma glucagon levels. (f) Plasma β‐hydroxybutyrate levels. (g) Plasma FFA levels. Values are the mean ± standard error of the mean (n = 5–6 mice/group). *P < 0.05, **P < 0.01 and ***P < 0.001. D, drug effect; D × F, drug and feeding condition interaction; F, feeding condition effect; T, time effect; T × D, time and drug interaction; T × F, time and feeding condition interaction; T × D × F, three‐way interaction.