Table 3.
Analgesic Outcomes by Buprenorphine/Methadone Group
| Buprenorphine n=99 | Methadone n=47 | P-value | |
|---|---|---|---|
| Delivery-to-discharge interval (days) | 3 [3, 4] | 3 [3, 4] | 0.555 |
| Time to first postoperative opioid request (minutes) | 64 [34, 106] | 79 [49, 138] | 0.140 |
| Oxycodone equivalents per 24 hours of hospitalization (mg) | 80.6 [62, 108.3] (range 7.9–257.5) | 76.3 [63, 105] (range 5–167.3) | 0.694 |
| Postoperative day 0 (0–24 hours) | 100 [75, 126.7] | 83.3 [63, 158.3] | 0.358 |
| Postoperative day 1 (24–48 hours) | 80 [60, 115] | 75 [50, 90] | 0.185 |
| Postoperative day 2 (48–72 hours) | 70 [40, 100] | 75 [50, 92.7] | 0.988 |
| Postoperative day 3 (72–96 hours) | 60 [30, 90] | 55 [43, 85] | 0.736 |
| Highest pain score each day (verbal 0–10 scale) | 8.3 [7, 9] (range 5–10) | 8.0 [7, 8.7] (range 5.3–10) | 0.518 |
| Postoperative day 0 (0–24 hours) | 9 [8, 10] | 9 [8, 10] | 0.816 |
| Postoperative day 1 (24–48 hours) | 8 [7, 9] | 8 [7, 9] | 0.631 |
| Postoperative day 2 (48–72 hours) | 8 [6, 9] | 8 [6, 8.5] | 0.699 |
| Postoperative day 3 (72–96 hours) | 7 [6, 8] | 8 [6, 9] | 0.247 |
| Lowest pain score each day (verbal 0–10 scale) | 2.5 [1.5, 3.5] | 2.1 [1.3, 3.3] | 0.510 |
| Postoperative day 0 (0–24 hours) | 3 [2, 5] | 3 [1.5, 4] | 0.280 |
| Postoperative day 1 (24–48 hours) | 2 [0, 4] | 2.5 [0.5, 4] | 0.740 |
| Postoperative day 2 (48–72 hours) | 3 [0, 4] | 2 [0, 4] | 0.900 |
| Postoperative day 3 (72–96 hours) | 0 [0, 3] | 0 [0, 4] | 0.950 |
| Ketorolac cumulative dose (mg) | 120 [120, 120] | 120 [120, 120] | 0.799 |
| Ibuprofen cumulative dose (mg) | 3200 [2667, 3200] | 3200 [2800, 3200] | 0.676 |
| Acetaminophen daily dose (mg) | 1083 [433, 1950] | 650 [379, 1110] | 0.022 |
| IV PCA use, n (%) | 8 (8%) | 11 (23%) | 0.010 |
| Hospital readmission, n (%) | 2 (2%) | 1 (2%) | 0.970 |
| Infection | 1 | 1 | |
| Bowel obstruction | 1 |
Notes: Data shown are n (%) for binary outcomes, and median [25th to 75th percentile range] otherwise.