Table 1.

Patient Demographics and Baseline Characteristics

Total Number	35
Age, mean±SD, (range)	67±4 (61–78)
Sex  Male  Female	6 (17%) 29 (83%)
Chronic pruritus Chronic prurigo nodularis	9 (40%) 21 (60%)
Duration of CP/CPN; number (%)  6-months-1 year  1–5 years  >5 years	10 (28%) 20 (57%) 5 (15%)
Baseline VAS, mean±SD, range	5.0±2.1; 3–9.8
Baseline VRS, mean±SD; range	1.7±0.7; 1–3
Baseline TEWL, g/m2/h	18±5.4
Baseline OTC parameters  Acanthosis, mean value  Hyperkeratosis, mean value  Plaque/Scale  Vascular sign	0.22 mm 0.045 mm Present in 19 subjects (55%) Reduced/absent in 15 subjects (44%)