Table 3.
Incidence Rate Ratios (IRRs) for TB by Risk Factor among Cancer Patients Based on Multiple Poisson Regression (n = 9,733)
| Variables | Cancer Patients (n) | TB cases (n) | Person time (person–year) |
IR (100,000 patients per year) |
Crude IRR | Adjusted IRR | 95%CI adjusted IRR |
p–value |
|---|---|---|---|---|---|---|---|---|
| Age | <0.001 | |||||||
| <= 50 | 2,711 | 52 | 11,470 | 453.31 | 1 | 1 | ||
| 51–60 | 2,177 | 52 | 5,220 | 996.94 | 2.2 | 1.63 | 1.09–2.43 | |
| 61–70 | 2,571 | 51 | 4,760 | 1070.52 | 2.36 | 1.52 | 1.01–2.27 | |
| > 70 | 2,334 | 51 | 2,830 | 1799.79 | 3.97 | 2.36 | 1.56–3.55 | |
| Total | 9,733 | 206 | 24,280 | |||||
| Gender | <0.001 | |||||||
| Female | 5,796 | 150 | 13,110 | 426.91 | 1 | 1 | ||
| Male | 3,937 | 56 | 11,170 | 1343.19 | 3.15 | 1.87 | 1.36–2.59 | |
| Total | 9,733 | 206 | 24,280 | |||||
| Cancer type* | <0.001 | |||||||
| Thyroid CA | 954 | 9 | 6,900 | 130.53 | 1 | 1 | ||
| Lung CA** | 1,231 | 22 | 1,460 | 1506.11 | 11.54 | 5.48 | 2.16–13.91 | |
| Lymphoma | 1,080 | 34 | 3,770 | 901.36 | 6.91 | 4.15 | 1.62–10.61 | |
| Hematopoietic | 1,790 | 54 | 5,250 | 1027.95 | 7.88 | 3.76 | 1.46–9.73 | |
| Digestive organ CA | 1,194 | 13 | 1,430 | 908.34 | 6.96 | 3.9 | 1.51–10.12 | |
| Urinary tract CA | 885 | 17 | 3,170 | 535.85 | 4.11 | 2.27 | 0.91–5.67 | |
| Lung CA*** | 2,599 | 57 | 2,300 | 2478.22 | 18.99 | 6.22 | 2.57–15.04 | |
| Total | 9,733 | 206 | 24,280 | |||||
| Cancer stage (by extent) | 0.476 | |||||||
| Local | 225 | 2 | 1,390 | 143.78 | 1 | 1 | ||
| Regional | 843 | 14 | 1,910 | 733.02 | 5.1 | 2.59 | 0.58–12.54 | |
| Distant | 2,196 | 29 | 2,310 | 1257.79 | 8.75 | 2.69 | 0.63–11.54 | |
| Not applicable | 2,033 | 67 | 6,340 | 1056.48 | 7.35 | 2.83 | 0.65–12.32 | |
| Unknown | 4,436 | 94 | 12,340 | 761.96 | 5.3 | 2.24 | 0.54–9.28 | |
| Total | 9,733 | 206 | 24,280 | |||||
| Cancer Treatment | ||||||||
| Only SURG | 1,253 | 19 | 5,180 | 367.08 | 1 | 1 | 0.05 | |
| No treatment | 5,184 | 120 | 7,550 | 1587.26 | 4.32 | 1.63 | 0.84–3.05 | |
| Only CMT | 1,782 | 44 | 5,470 | 804.51 | 2.19 | 0.94 | 0.47–1.88 | |
| Only RT | 459 | 7 | 960 | 730.09 | 1.99 | 1.12 | 0.43–2.89 | |
| SURG+CMT | 346 | 4 | 1,220 | 328.76 | 0.9 | 0.47 | 0.16–1.40 | |
| SURG+RT | 401 | 4 | 2,890 | 138.44 | 0.38 | 0.91 | 0.28–2.97 | |
| CMT + RT | 258 | 7 | 850 | 822.05 | 2.24 | 0.97 | 0.37–2.55 | |
| SURG+CMT+RT | 50 | 1 | 160 | 613.13 | 1.67 | 1 | 0.13–7.63 | |
| Total | 9,733 | 206 | 24,280 |
Remark; IRR, Incidence rate ratio; 95% CI , 95% confidence interval; 1, Reference group; SURG, surgery; CMT, chemotherapy; RT, Radiotherapy; *, Included only 7 cancer types in the multiple poisson regression; **, Lung cancer with histological confirmation; ***, Lung cancer without histological confirmation