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. 2020 Dec 21;11:615327. doi: 10.3389/fimmu.2020.615327

Figure 1.

Figure 1

Dose-dependent changes following the preemptive (16 h and 1 h before CCI) and then repeated i.t. administration of cenicriviroc in concentrations of 5 µg, 20 µg, and 40 µg/5 µl [(A) administration scheme] on pain-related behaviors [(B, C) von Frey test; (D, E) cold plate test] on day 7 post CCI, 30 min or 60 min after cenicriviroc or vehicle injection. Data are presented as the mean ± SEM (n = 7–10 per group). Intergroup differences were analyzed by ANOVA with Bonferroni’s multiple comparisons test. ***p < 0.0001, **p < 0.01 indicates differences between naive and CCI-exposed rats; ###p < 0.001, ##p < 0.01, #p < 0.05 indicates differences between V-treated and CVC-treated CCI-exposed rats. The dotted line shows the cut-off value. CCI, chronic constriction injury; CVC, cenicriviroc; N, naive; V, vehicle.