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. 2020 Dec 21;11:615327. doi: 10.3389/fimmu.2020.615327

Figure 4.

Figure 4

Changes in mRNA (A–C, G–I) and protein (D–F, J–L) levels of IL-1beta, IL-6 and IL-18 in the spinal cord (A–F) and DRG (G–L) on day 7 post CCI after repeated vehicle or cenicriviroc (20 µg/5 µl, i.t.) administration, measured using RT-qPCR and Western blot method. Data are presented as the mean ± SEM (n = 5–10 per group for mRNA analysis and n = 5-7 per group for protein analysis). Intergroup differences were analyzed by ANOVA with Bonferroni’s multiple comparisons test. ***p < 0.001, **p < 0.01, *p < 0.05 indicate differences between naive and V-treated/CVC-treated CCI-exposed rats; ###p < 0.001, #p < 0.05 indicate differences between V-treated and CVC-treated CCI-exposed rats. CCI, chronic constriction injury; CVC, cenicriviroc; N, naive; V, vehicle.