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. 2020 Dec 21;8:592433. doi: 10.3389/fcell.2020.592433

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Copyright © 2020 Luo, Zhang, Li, Liu, Yao, Guo, Jin, Jin, Yuan, Jiang and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram of the effects of IMP on oocyte aging. After treatment of IMP, intracellular ROS, apoptosis, and autophagy levels were decreased, while activity of CAT and SOD as well as mitochondria function (ATP production) were increased in aged oocyte. IMP-treated aged oocytes also showed significantly higher levels of MPF (MOS, CCNB1, BMP15, and GDF9) and well cortical granule distribution. These may help oocyte delay aging process.