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. 2020 Dec 21;8:614139. doi: 10.3389/fcell.2020.614139

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Copyright © 2020 Cong, Guo, Cheng, He, Zhao, Kong, Ning and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of various molecules and hallmark pathways in the four subtypes. (A) The expression of chemokines and chemokine receptors in the four subtypes. (B) The expression of immune checkpoints in the four subtypes. (C) The expression of MHC class I and II molecules in the four subtypes. (D) The expression of hypoxia-related genes in the four subtypes. (E) The GSVA score of the hallmark pathways in the four subtypes (statistical comparison between the multivariate groups was performed by Kruskal-Wallis test. ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).