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Changes of various factors caused by obesity on the regulation of bone disease. Obesity can increase mechanical load, visceral fat and bone marrow fat. In addition, obesity is associated with increased adipokines, increased TNF – or, IL-1, IL- 6, decreased vitamin D, and accompanied by hypertension, dyslipidemia, and dysglycemia. They regulate bone disease by affecting bone formation, bone resorption, and cartilage.
