TABLE 3.
Blood coagulation test results of 1,643 patients with COVID-19.
| Covariate | All patients (n = 1,643) median (IQR)/n (%) | Normal D-Dimer (n = 952) median (IQR)/n (%) | Elevated D-Dimer (n = 691) median (IQR)/n (%) | p Value | References range |
|---|---|---|---|---|---|
| Prothrombin time, s | 11.3 (10.9–11.8) | 11.2 (10.8–11.6) | 11.4 (11.0–12.1) | <0.001 | 9.4–12.5 |
| 9.4–12.5 | 1,511 (92.0) | 913 (95.9) | 598 (86.5) | <0.001 | |
| <9.4 | 1 (0.1) | 1 (0.1) | 0 (0) | ||
| >12.5 | 131 (8.0) | 38 (4.0) | 93 (13.5) | ||
| International normalized ratio | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) | 1.0 (0.9–1.1) | <0.001 | 0.8–1.3 |
| 0.8–1.3 | 1,616 (98.4) | 945 (99.3) | 671 (97.1) | <0.001 | |
| <0.8 | 1 (0.1) | 1 (0.1) | 0 (0) | ||
| >1.3 | 26 (1.6) | 6 (0.6) | 20 (2.9) | ||
| Activated partial thromboplastin time, s | 27.2 (24.6–30.4) | 27.2 (24.7–30.3) | 27.2 (24.3–30.9) | 0.673 | 25.1–36.5 |
| 25.1–36.5 | 1,070 (65.1) | 638 (67.0) | 432 (62.5) | 0.147 | |
| <25.1 | 485 (29.5) | 268 (28.2) | 217 (31.4) | ||
| >36.5 | 88 (5.4) | 46 (4.8) | 42 (6.1) | ||
| Fibrinogen, (g/L) | 2.95 (2.51–3.73) | 2.80 (2.40–3.30) | 3.43 (2.71–4.08) | <0.001 | 2.38–4.98 |
| 2.38–4.98 | 1,038 (63.2) | 639 (67.1) | 399 (57.7) | <0.001 | |
| <2.38 | 316 (19.2) | 227 (23.8) | 89 (12.9) | ||
| >4.98 | 289 (17.6) | 86 (9) | 203 (29.4) | ||
| Thrombin time, s | 17.6 (17.0–18.4) | 17.7 (17.2–18.5) | 17.4 (16.7–18.3) | <0.001 | 10.3–16.6 |
| 10.3–16.6 | 248 (15.1) | 88 (9.2) | 160 (23.2) | <0.001 | |
| <10.3 | 1,341 (81.6) | 831 (87.3) | 510 (73.8) | ||
| >16.6 | 54 (3.3) | 33 (3.5) | 21 (3.0) | ||
| D-dimer, g/L | 0.39 (0.21–0.91) | 0.24 (0.16–0.33) | 1.08 (0.74–2.2) | <0.001 | 0–0.50 |